Job Description

Scientist/Associate Scientist, In vivo pharmacology

A well-funded and highly innovative start up from Third Rock Ventures is emerging out of stealth with a syndicate of marquee investors and is seeking a talented Scientist/Associate Scientist (AS) to join the Biology-In vivo pharmacology team. The Scientist/AS will support the in vivo pharmacology team for discovery-stage pipeline program(s) focused on antibody-driven diseases. The role will work collaboratively with the Biology team lead(s) to contribute to lead characterization and development candidate selection. The Scientist/AS will aid in the management of both external and internal in vivo pharmacology studies and contribute to the growth of internal in vivo capabilities. The ideal candidate is an experienced lab-based biologist with a background in immunology and biologics drug discovery.

Responsibilities :

• Design and carry out in vivo biology experiments that support preclinical drug discovery including PK/PD analysis, mechanism of action studies, and disease modeling
• Aid in expanding our internal in vivo pharmacology capabilities at a shared vivarium space, including animal handling, dosing, sample collection/processing
• Independently develop and execute quantitative assays for the analysis/characterization of ex vivo samples (ELISA, flow cytometry, etc.)
• Work collaboratively with peer team leads to advance program(s) to IND
• Proactively review literature to bring in newest scientific findings, ideas, and methods/technologies for discovery research
• Manage out-sourced CRO-based workflows, including study design and data analysis

Required qualifications and experience:

• PhD with 0-3 years or a Bachelors with 8+ years or Masters with 6+years in relevant scientific area, such as immunology, cell/molecular biology with
• Experience in the design and execution of in vivo studies (experience assessing pharmacokinetics/pharmacodynamics of biologics preferred)
• Experience with ex vivo sample analysis and data interpretation (ELISA, immunophenotyping)
• Capacity to work within a dynamic matrix environment, with strong contributions to project strategy and execution
• Excellent communication, presentation, and inter-personal skills; superb organizational and problem-solving skills

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